Antigen epitope ofHelicobacter pylorivacuolating cytotoxin A

Human leukocyte antigen epitope antigenicity and immunogenicity.

PURPOSE OF REVIEW Human leukocyte antigen (HLA) antibodies are now recognized as being specific for epitopes which can be defined structurally with amino acid differences between HLA alleles. This article addresses two general perspectives of HLA epitopes namely antigenicity, that is their reactivity with antibody and immunogenicity, that is their ability of eliciting an antibody response. RE...

Antigen epitope-expressing cytokines for DNA immunization.

Strategies to enhance the efficacy of DNA vaccination against malignancy remain to be established. In this study, a plasmid expressing a tumor antigen incorporated into the signal peptide of human IL-2 was tested as a DNA vaccine in a murine model system. Results showed that antigen-specific CTL responses were elicited by intramuscular injection of these plasmids. Importantly, compared with a m...

Identification and Epitope Optimization Throughput Method for Antigen Solid-Phase Epitope Recovery: A High

فراوانی آنتی‌بادی ضد Cytotoxin associated Gene A در استان گلستان

زمینه و هدف : سویه‌های باکتری هلیکوباکترپیلوری که دارای پروتئین Cag A (Cytotoxin associated Gene A) می‌باشند؛ استعداد بیشتری برای ایجاد بیماری دارند. این پروتئین بیماری‌زایی باکتری را با افزایش تولید سیتوتوکسین در سلول میزبان تسریع می‌نماید. این مطالعه به منظور تعیین فراوانی آنتی‌بادی ضد CagA در افراد آلوده به هلیکوباکترپیلوری در استان گلستان انجام شد. روش بررسی : این مطالعه توصیفی روی 676 ...

B and T-Cell Epitope Prediction of the OMP25 Antigen for Developing Brucella melitensis Vaccines for Sheep

Brucellosis, produced by Brucella species, is a disease that causes severe economic losses for livestock farms worldwide Due to serious economic and medical consequences of this disease, many efforts have been made to prevent the infection through the use of recombinant vaccines based on Brucella outer membrane protein (OMP) antigens. In the present study, a wide range of on-line prediction sof...